Enhancing hepatoprotective action: oxyberberine amorphous solid dispersion system targeting TLR4
Abstract Oxyberberine (OBB) is a significant natural compound, with excellent hepatoprotective properties.However, the poor water Scarf solubility of OBB hinders its release and absorption thus resulting in low bioavailability.To overcome these drawbacks of OBB, amorphous spray-dried powders (ASDs) of OBB were formulated.The dissolution, characteri